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| 产品编号 | D50402 |
| 英文名称 | EX-527 |
| 中文名称 | |
| 别 名 | EX 527 (Selisistat); 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; EX527 cpd; Selisistat; SEN0014196; SIRT1 Inhibitor III; HY-15452; Selisistat (EX 527); SIRT1 Inhibitor; EX-527 6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺; |
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Specific References (1) | D50402 has been referenced in 1 publications.
[IF=3.329] Su, Pei-Pei. et al. Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy. MILITARY MED RES. 2022 Dec;9(1):1-13 Mouse.
PubMed:35614465
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| 保存条件 | Store at -20℃ stable for at least 12 months. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | CAS：49843-98-3 分子式：C13H13ClN2O 分子量：248.71 MDL：MFCD03009471 纯度：≥98% 熔点：178℃ 沸点：531.72℃/760mmHg 溶解性：Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), DMF (~20 mg/ml), and DMSO:PBS (1:1 pH 7.2) (~0.5 mg/ml). 溶解性：Water <1mg> 作用靶点：Sirtuin; 作用通路：Cell Cycle/DNA Damage; Epigenetics; 用途及描述：Selisistat (EX-527) 是一种有效，选择性的 SIRT1 抑制剂，IC50 为 98 nM。对SIRT2和SIRT3极弱的抑制作用。 |