pLP2载体说明书
| 型号 | 载体名称 | 出品公司 | 载体用途 |
| VMI0383 | pLP2 | Invitrogen | 慢病毒包装载体 |
Zeocin™ belongs to a family of structurally related bleomycin/phleomycin-type
antibiotics isolated from Streptomyces. Antibiotics in this family are broad
spectrum antibiotics that act as strong antibacterial and antitumor drugs. They
show strong toxicity against bacteria, fungi （including yeast）, plants, and
mammalian cells （Baron et al., 1992; Drocourt et al., 1990; Mulsant et al., 1988;
Perez et al., 1989）.
The Zeocin™ resistance protein has been isolated and characterized （Calmels et
al., 1991; Drocourt et al., 1990）. This protein, the product of the Sh ble gene
（Streptoalloteichus hindustanus bleomycin gene）, is a 13.7 kDa protein that binds
Zeocin™ and inhibits its DNA strand cleavage activity. Expression of this protein
in eukaryotic and prokaryotic hosts confers resistance to Zeocin™.