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Pefachrome^â6017

Application:	Highly sensitive chromogenic peptide substrate for factor XIIa. Determination of factor XIIa
	activity for research, in-process and quality control.
Formula:	H-D-CHA-Gly-Arg-pNA×2AcOH	MW:	624.7
Principle:	H-D-CHA-Gly-Arg-pNA + FXIIa ==> H-D-CHA-Gly-Arg-OH + pNA + FXIIa
KM:	0.8 mM	vmax:	3.14 mmol/min

Solubility: Up to 4 mM in H₂O

Storage: May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

Material required but not provided:

Buffer, NaCl, reference material, dist. H₂O, Pefabloc^â PK, Kalliplastin^â

Buffer: 50 mM Tris-imidazole buffer pH 7.9, 150 mM NaCl

Assay 1: Suggested protocol for the determination of factor XIIa activity:

0.700 ml buffer0.100 ml factor XIIa (0.2 units/ml)

0.200 ml Pefachrome^â6017 4 mM

==> Determination of DOD/min at 405 nm 

Assay 2: Suggested protocol for the determination of factor XIIa activity (FXII activated by Kalliplastin^â) using Pefachrome^â6017 and a selective synthetic inhibitor of plasma kallikrein (Pefabloc^â PK):

0.100 ml citrated plasma (diluted 1:5 with NaCl)

0.200 ml Kalliplastin^â (20 mg/ml, Pentapharm Ltd.) ð incubate for 1 min at 37 ^oC

0.500 ml buffer

0.100 ml Pefabloc^â PK 0.2 mM

0.100 ml Pefachrome^â6017 2 mM

==> Determination of DOD/min at 405 nm 

Reference: Stürzebecher J, Svendsen L, Eichenberger R, Markwardt F.

A new assay for the determination of factor XII in plasma using a chromogenic substrate and a selective inhibitor of plasma kallikrein.

Thromb Res 1989; 55: 709-15.

 

Package size:	Vial containing 10 mmol	Code:	081-45
	Bulk [g]		081-11
	FOR RESEARCH USE ONLY. NOT FOR HUMAN USE OR DRUG USE.
[Data sheet / 5802]	âRegistered Trademark of Pentapharm

 

REF	NAME	CHEMICAL FORMULA
081-11	Pefachromeâ6017	H-D-CHA-Gly-Arg-pNA · 2AcOH