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APE 1
- Apurinic/apyrimidinic Endonuclease 1
- DNA AP endonuclease that catalyzes the cleavage of DNA phosphodiester backbone at AP sites via hydrolysis leaving a 1 nucleotide gap with 3′-hydroxyl and 5′ deoxyribose phosphate (dRP) termini
- APE 1 has also been reported to have DNA 3′-diesterase, 3′ to 5′ exonuclease, and RNase H activities
- Also known as HAP1 or Ref-1
