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SNAP-Surface® Block
SNAP-Surface® Block (C8 propanoic acid benzylguanine, CBG) is a nonfluorescent compound that blocks the reactivity of the SNAP-tag® in solution or on the surface of living cells.
- It is largely membrane impermeable essentially limiting blocking to cell surface-exposed SNAP-tags
- Once it reacts with the SNAP-tag, it irreversibly inactivates it for subsequent labeling steps
- It can be used to generate inactive controls in live cell labeling experiments performed with SNAP-tag fusion proteins
