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Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.
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Applications:
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• Western Blot
• IHC
• ChIP
• Flow Cytometry
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| HDAC Antibodies |
| HDAC-1 |
HDAC-6 |
| HDAC-2 （Ab-394） |
HDAC-7 |
| HDAC-3 |
HDAC-7 （Ser155） |
| HDAC-4 |
HDAC-7 （Ser318） |
| HDAC-4 （Ab-632） |
HDAC-7 （Ser448） |
| HDAC-4 （Ser632） |
HDAC-8 （Ab-39） |
| HDAC-5 |
HDAC-8 （Ser39） |
| HDAC-5 （Ab-498） |
HDAC-9 |
| HDAC-5 （Ser498） |
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| Dnmt Antibodies |
| Dnmt1 |
Dnmt3a |
| Dnmt2 |
Dnmt3b |
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Related Pathways
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| Transcription Factors |
| Apoptosis Detection Kits/pSIVA |
| NF-kB Pathway |
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| Dnmt3a, IMG-268A |
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Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium （OE）. DNMT3a （red） is co-expressed with neuron-specific tubulin （green） throughout the development of the olfactory epithelium, using IMG-268A. （Data courtesy of A. Jane Roskams, University of British Columbia）.
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| HDAC-7 （Ser155）, IMG-612 |
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Western blot analysis of phosphorylated HDAC-7 in （A） recombinant fusion protein containin a phosphorylated serine at position 155 and （B） fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.
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