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PEVIVA产品线是在斯德哥尔摩的Karolinska研究所发明的，并且基于测量细胞凋亡和总细胞死亡的*抗体。自发明以来，该产品已在范围内在学术界，工业界和医疗界使用。测量细胞凋亡和总细胞死亡水平在开发新药物时以及评估药物和其他物质的毒理作用时，对于患有肝脏疾病如NASH和ASH的患者的诊断和治疗后续行动是有意义的。
M30 CYTODEATH™
The M30 CytoDEATH™ antibodies
Recommended applications
The M30 CytoDEATH™ mouse monoclonal antibodies detect the formalin-resistant M30 neo-epitope on human, monkey and bovine caspase-cleaved keratin 18, and are recommended for the following applications:
✔ Western blot (WB)
✔ Immunocytochemistry (ICC)
✔ Flow cytometry (FACS)
✔ Immunohistochemistry (IHC) including formalin-fixed and paraffin-embedded tissue sections (PS) and cryostat sections (FS)
The M30 CytoDEATH™ antibodies
The M30 CytoDEATH™ mouse monoclonal antibody is available unlabelled or conjugated with different fluorescent molecular probe dyes.
M30 CytoDEATH™ (unlabelled), prod. no. 10700
M30 CytoDEATH™ Biotin, prod. no. 10750
M30 CytoDEATH™ Fluorescein, prod. no. 10800
M30 CytoDEATH™ Orange, prod. no. 10830
M30 CYTODEATH™ ELISA
Product nr. 10900
The Product
The M30 CytoDeath™ ELISA offers a unique possibility to measure human cell death by apoptosis in cell cultures, multicellular spheroids and organ culture systems. The M30 CytoDeath™ ELISA is a product developed for cell culture applications, with a dynamic range and sensitivity suitable for in vitro work, making it a useful drug screening tool.
The assay, M30 CytoDeath™ ELISA, is based on the unique M30 antibody that recognizes a neo-epitope of keratin 18 (K18), formed after caspase cleavage during apoptosis.
Application Fields
Oncology
The M30 CytoDeath™ ELISA measures chemotherapy or anti-cancer drug induced apoptosis in epithelial carcinoma
Toxicology
Suitable for in vitro characterization of apoptosis-inducing drugs, including establishment of time course kinetics and dose-response relationships