Enzyme HFXIIa 1212a说明书

 

Enzyme Research Laboratories公司是一家致力于提供高纯度凝血因子相关产品的生物高科技公司,供应的产品包括纯化的人/牛血浆蛋白(包括多种凝血因子)、重组蛋白、Immune Depleted Plasmas、凝血/血栓研究相关抗体。产品广泛应用于生物技术、生物制药、医院及研究所的科研等众多领域。作为该领域的行业先进者,Enzyme Research Laboratories在近十年间为止血及血栓症研究提供了的产品支持。除了成熟的产品线外,Enzyme Research Laboratories公司凭借多年的研发和鉴定经验,还提供蛋白/多肽测序、多肽合成、寡核苷酸合成、氨基酸谱分析等定制研究服务。

人因子α-XIIa

人因子αXIIa(活化的Hageman因子)
目录编号:HFXIIa 1212a 
大小:0.5毫克,1.0毫克

人因子α-XIIa是丝氨酸蛋白酶,其负责在接触激活系统中激活因子XI至XIa。人因子XII和前激肽释放酶被认为参与相互激活机制,其中因子XIIa将前激肽释放酶激活为激肽释放酶,激肽释放酶又将因子XII转化为XIIa。因子XIIa激活因子XI至XIa,从而触发接触因子级联。ERL提供因子α-XIIa,其通过硫酸葡聚糖的自激活过程活化并重新纯化以除去活化剂。通过SDS-PAGE测定蛋白质纯度,并通过凝固测定确定活性。

缓冲液组成= 4 mM醋酸钠-HCl / 0.15 M NaCl / pH 5.3 
消光系数(1%)= 14.1 

Human Factor Alpha-XIIa 

Human Factor αXIIa (Activated Hageman Factor)
Catalog Number: HFXIIa 1212a
Size: 0.5 mg, 1.0 mg

Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. ERL offers Factor α-XIIa which is activated by the autoactivation process with Dextran Sulfate and re-purified to remove the activator. The protein purity is determined by SDS-PAGE and activity is determined via clotting assay.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
Extinction Coefficient (1%) = 14.1
Molecular Weight = 80,000 daltons

 

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HFXIIa 1212a Factor XIIa 4-6周到货 5556 1.0 mg Enzyme research2018
HFXIIa 1212a Factor XIIa 4-6周到货 4716 0.5 mg Enzyme research2018

 

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人类α凝血因子(Human Factor αXIIa)HFXIIa 1212a说明书

 Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。

Enzyme Research Laboratories为生物技术公司,制药行业、医院和大学的研究实验室提供用于的纯化抗凝因子。除了其制造能力,Enzyme Research Laboratories也创新研发领域中的血液凝固技术。

Human Factor αXIIa

 

HFXIIa 1212a             Human Factor αXIIa 
                              (Activated Hageman Factor)

Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. ERL offers Factor α-XIIa which is activated by the autoactivation process with Dextran Sulfate and re-purified to remove the activator. The protein purity is determined by SDS-PAGE and activity is determined via clotting assay.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient (1%) = 14.1
Molecular Weight = 80,000 daltons