体外研究：
AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

体内研究：
AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.

基本信息：

CAS号：329-98-6
分子式：C7H7FO2S
分子量：174.19
MDL：MFCD00007424
级别：BR
纯度：≥99.0% (HPLC)
外观/性状：白色至奶白色固体
溶解性：可溶于异丙醇、乙醇、甲醇、二甲苯和石油醚。难溶于水，且在水溶液中非常不稳定，容易分解。
敏感性：易吸潮

产品简介：
苯甲基磺酰氟 (PMSF) 是一种不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。
可抑制丝氨酸蛋白酶例如胰蛋白酶(trypsin)和胰凝乳蛋白酶(chymotrypsin)，也可抑制半胱氨酸蛋白酶和乙酰胆碱酯酶。用异丙醇溶解后分装成小包装-20℃保存。有效浓度为0.1-1mM。
溶液配制：将 PMSF 溶于异丙醇，浓度为 1.74 mg/mL (10 mM)；在 -20°C 分装保存，避免反复冻融。
作用靶点：Cannabinoid Receptor;
作用通路：Metabolic Enzyme/Protease;
体外研究：Neurological Disease