冈田酸

上海金畔生物科技有限公司提供冈田酸 ,欢迎访问官网了解更多产品信息。

产品编号 D50453
英文名称 Okadaic acid
中文名称 冈田酸
别    名 OA; Okadaic A; 35-Demethyldinophysistoxin 1 solution; 35-Demethyl-DTX 1 solution; NSC 677083; PP1&PP2A inhibitor; PP1 and PP2A inhibitor; Okadaic acid potassium salt from Prorocentrum;   冈田(软海绵)酸; 软海绵酸; 黑海棉酸; 冈田酸/软海绵酸; 冈田酸 钾盐 来源于凹形原甲藻;
浓    度 1mg/ml
保存条件 Store at -20℃ stable for 24 months.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 基本信息:
CAS:155751-72-7
分子式:C44H67KO13

分子量:843.09

MDL:MFCD00214356

纯度:≥90% (HPLC), powder

溶解性:溶于乙醇(5 ug/50 ul = 124.2 μM)

产品简介:
冈田酸 (Okadaic acid) 是一种海洋毒素,是蛋白质磷酸酶 (PP) 的抑制剂,包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM),其中对 PP2A 的亲和力最显著,但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化,并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
作用靶点:Phosphatase; Apoptosis;
作用通路:Metabolic Enzyme/Protease; Apoptosis

体外研究:
Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[3]

体内研究:
Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]

REFERENCES:
[1]. Kleppe R, et al. Cell Death Inducing Microbial Protein Phosphatase Inhibitors–Mechanisms of Action. Mar Drugs. 2015 Oct 22;13(10):6505-20.
[2]. Valdiglesias V, et al. Okadaic acid: more than a diarrheic toxin. Mar Drugs. 2013 Oct 31;11(11):4328-49.
[3]. del Campo M, et al. Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines. Mar Drugs. 2013;11(12):4751-4760.
[4]. Cho MH, et al. Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons. Brain Res. 2012 May 15;1454:100-10.
[5]. Baker S, et al. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathol Commun. 2016;4:32.

冈田酸钾盐

上海金畔生物科技有限公司提供冈田酸钾盐 ,欢迎访问官网了解更多产品信息。

产品编号 D50454
英文名称 Okadaic acid potassium salt
中文名称 冈田酸钾盐
别    名 OA; PP1&PP2A inhibitor; PP1 and PP2A inhibitor;   冈田酸 钾盐 来源于凹形原甲藻;
浓    度 1mg/ml
保存条件 Store at -20℃ stable for 24 months.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 基本信息:
CAS:155751-72-7
分子式:C44H67KO13
分子量:843.09
纯度:>98%
溶解性:溶于DMSO(10 ug/50 ul = 242.4 μM)
产品简介:
冈田酸钾盐 (Okadaic acid potassium salt) 是一种海洋毒素,是蛋白质磷酸酶 (PP) 的抑制剂,包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM),其中对 PP2A 的亲和力最显著,但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化,并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
作用靶点:Phosphatase; Apoptosis;
作用通路:Metabolic Enzyme/Protease; Apoptosis